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From200US$ /night
Check-in
26Nov2025Select date
Check-out
27Nov2025Select date
Rooms and Guests2 Guests, 1 Room
Key details

About the Hotel

700 West Main Street, Louisville, Kentucky, United States, 40202
Perfect
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9.3
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Rooms & Suites

21c Museum Hotel Louisville offers 91 rooms with original artwork, including Atrium Suites with king-sized beds, living and dining areas, and tubs with walk-in showers. The Corner Suite features four large windows overlooking 7th Street, Main Street, and the Ohio River. The Asleep in the Cyclone suite is an immersive artist-designed space with a king-sized platform bed, a record player, and custom linens. All rooms include a Bryte Restorative Sleep Bed, 50-55' HDTVs, Lavazza coffee, and Malin+Goetz bath amenities.

Dining at Proof

Proof on Main serves Southern and Appalachian-inspired cuisine, led by Kentucky native Chef Cody Stone. The lounge houses the 21c Selects Private Barrel Program, featuring regional bourbons. The Fork & Bottle dinner series highlights guest distillers, while the Hog & Barrel dinner includes Pappy Van Winkle tastings.

Art & Events

The hotel includes over 9,000 square feet of exhibition space with rotating contemporary art installations like Fragile Figures: Beings and Time and Tredici Cavalli [13 Horses], made entirely of duct tape. Events include dance performances inspired by the art, curated dinners, and weddings in gallery spaces. The museum is open 24/7 and free to the public.

Downtown Location

The hotel is on Main Street, a half-mile from the Kentucky Museum of Art & Craft, Frazier History Museum, and Muhammad Ali Center. The free ZeroBus stops two blocks away, connecting to Whiskey Row, Slugger Field, and other downtown sites. Old Forester Distillery, known as 'the first bottled bourbon,' is nearby.

Services & Amenities

Guests can book deep tissue or sports massages, use the 24-hour fitness center, or relax in the sauna and steam room. Event planners offer eco-conscious meeting options, and catering menus are tailored to group needs. Valet parking is available, and pet-friendly rooms are offered.

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Choose the Room

From cosy doubles to spacious family suites – all with flexible options, breakfast, and exclusive deals.
Room Balcony
2 persons
29 m² 
1 King-size bed
Shower
Coffee machine
Deluxe King Room
2 persons
31 m² 
1 King-size bed
Shower
Coffee machine
Corner Suite
2 persons
61 m² 
1 King-size bed
Shower
Coffee machine
Deluxe King Suite
2 persons
46 m² 
1 King-size bed
Shower
Coffee machine
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Check Dates & Room Rates

See what's available for your travel dates

Getting around

All Transportation Options at a Glance

City Centre
Louisville 1.9 km
Airports
Louisville (SDF) 11.9 km

Amenities

Thoughtfully designed amenities for a comfortable & memorable stay

General

  • No smoking on site
  • Free Wi-Fi
  • Parking
  • Safe deposit box
  • 24-hour reception
  • Pets allowed
  • Rooms/ Facilities for disabled
  • Wheelchair access
  • Security
  • Luggage storage
  • Locker room
  • Allergy-free rooms
  • Lift
  • ATM/Cash machine
  • Smoke detectors
  • Electric vehicle charging station
  • Fire extinguishers

Sports & Fitness

  • Fitness centre
  • Yoga class

Guest Parking

  • Cookware/ Kitchen utensils

Services

  • Valet parking
  • Room service
  • Housekeeping
  • Laundry
  • Dry cleaning
  • Welcome drink

Dining

  • Restaurant
  • Bar/ Lounge area
  • Outdoor dining area

Business

  • Business centre
  • Meeting/ Banquet facilities
  • Fax/Photocopying

Children

  • Cots

Spa & Leisure

  • Spa & wellness centre
  • Sauna
  • Turkish bath
  • Steam room
  • Full body massage

Room features

  • Air conditioning
  • Heating
  • Mini-bar
  • Soundproofed rooms
  • Patio
  • Tea and coffee facilities
  • Ironing facilities

Bathroom

  • Free toiletries

Self-catering

  • Cookware/ Kitchen utensils

Media

  • Flat-screen TV

Room decor

  • Carpeted floor
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Location

700 West Main Street, Louisville, Kentucky, United States, 40202
Map view
700 West Main Street, Louisville, Kentucky, United States, 40202
Nearby
Museum
Louisville Slugger Museum & Bat Factory
180 m
Museum
Muhammad Ali Center
280 m
Museum
Kentucky Science Center
140 m
Museum
The Frazier History Museum
260 m
Museum
Kentucky Museum of Art and Craft
70 m
528 W Main St
Evan Williams Bourbon Experience
200 m
Gallery
Flame Run Glass Studio and Gallery
300 m
500 W Main St
The Belvedere
250 m
Night club
Jimmy Can't Dance
90 m
801 W Main St
Michter's Fort Nelson Distillery
150 m
Library
Sons of the American Revolution Genealogical Research Library
190 m
120 N 10th St
Kentucky Peerless Distilling Co
480 m
401 W River Rd
Belle of Louisville Riverboats
580 m
Restaurants
Proof On Main
10 m
702 West Main Street
Mussel & Burger Bar Downtown
60 m
113 S 7th St Located in Louisville's Central Business District
Bristol Bar & Grille
110 m
614 W Main St
Atlantic No. 5
160 m
605 W Main St Located in Louisville's Central Business District.
Los Aztecas Mexican Restaurant
180 m
445 E Market St
Vincenzo's Italian Restaurant
430 m
150 S 5th St
Jockey Silks Bourbon Bar
480 m
140 N 4th St 2nd Floor - West Tower
Dish on Market
470 m
434 W Market St
Quiznos
540 m
223 S 5th St
Swizzle Dinner & Drinks
530 m
140 N Fourth St 25th Floor
Cafe Magnolia
590 m
140 N 4th St Galt House Hotel
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Check-in
26Nov2025Select date
Check-out
27Nov2025Select date
Rooms and Guests2 Guests, 1 Room